Tokyo Tech and Kawasaki City join forces in R&D

The program fuses computational drug design that utilises molecular simulation and machine learning by the Super Computer TSUBAME of Tokyo Tech and unique chemical synthesis technology such as artificial peptides and artificial nucleic acids.

Through industry-academia-government partnerships including corporations in Kawasaki City, the program seeks to form an innovation ecosystem that bridges basic/fundamental research and the drug discovery business, thus dramatically improving the efficiency of developing middle molecule drugs.

In order to implement this research project, the Middle Molecule IT-based Drug Discovery Laboratory (MIDL) will be opened this fiscal year in Tonomachi KING SKYFRONT, an international strategic zone located in Kawasaki City.

MIDL will possess enhanced research functions for middle molecules and will be the world's first dedicated facility in this field with state-of-the-art computational approaches. Tokyo Tech will also open a Middle Molecule IT-based Drug Discovery Laboratory (MIDL) core facility inside the university campus and establish a system in which faculty cooperate across research fields.

This research program was selected for support by the FY2017 Regional Innovation and Ecosystem Formation Program of the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT).

The MEXT program seeks to utilise regional technology seeds and to create a successful model of industrialisation with significant social impact based on global expansion from that region.

During the 5-year period until March 2022, the research program will receive annual grants-in-aid of 155 million JPY. The grants will be used to conduct R&D, to construct an infrastructure for creating a regional industrial ecosystem, and to implement a business promotion program.

Middle molecules refer to peptides, nucleic acids, and other molecules with a molecular weight of about 500 to 30,000. Conventional drug discovery mainly consisted of synthesising small molecules with a molecular weight under 500; in other words, "small molecule drug discovery." In recent years, there has been new drug discovery using large molecules for antibodies such as the anticancer drug OPDIVO.

However, industrial synthesis is difficult and poses numerous issues such as the extremely high cost incurred for creation using animal cells under advanced control conditions. Middle molecules enable chemical synthesis while offering various benefits that are similar to large molecules.

As such, middle molecules are expected to fulfill a leading role in new drug discovery. The efficiency of development is significantly increased through knowledge processing, machine learning and molecular simulation that utilises information technology (IT) for computational analysis in a variety of stages from supporting decision-making for drug discovery target molecules and selecting actual candidate compounds to determining bio-stability, membrane permeability, and toxicity.

Tonomachi KING SKYFRONT is a global innovation hub attracting the world's leading corporations and laboratories in the areas of health, medicine, welfare and environment. Also designated as a special zone under the country's new growth strategy, various privileges are offered to those operating at KING SKYFRONT.　

Tokyo Tech research institute MIDL that is scheduled to be opened at KING SKYFRONT will construct a research system that integrates researchers from different fields and will strength partnerships among IT, chemical, and drug discovery corporations in Kawasaki City.

Corporations currently participating in the research program are as follows: Institute of Industrial Promotion Kawasaki; Kawasaki Shinkin Bank; The Bank of Yokohama, Ltd.; Hamagin Research Institute, Ltd.; Innovations and Future Creation Inc.; Fast Track Initiative, Inc.; MVP Inc.; PeptiDream Inc.; Level Five Co., Ltd.; IMSBIO Co., Ltd.; Catalyst Inc.; Modulus Discovery, Inc.

Yutaka Akiyama, Professor at the School of Computing at Tokyo Tech, said, "Computational prediction for the bio-stability and cell membrane permeability of middle molecules is very challenging".

"By using Tokyo Tech's world-leading supercomputing techniques and extensive experience in machine learning, and by cooperating with many related corporations, I hope that MIDL will provide the world with practical technology for accelerating middle molecule drug discovery."

"We are excited about this collaboration with Tokyo Tech, establishing an innovative research base for rapidly growing middle molecule drug discovery at our international strategic zone "KING SKYFRONT."

In cooperation with Tokyo Tech, we would like to make every effort to form an innovation ecosystem working with corporations in Kawasaki" said Shigeyuki Shiratori, Director of International Strategy Promotion Department, Coastal Area International Strategy Headquarters, City of Kawasaki.

By accelerating the design of middle molecule drug discovery and the development of pharmaceuticals, this research program will resolve various issues such as the increased cost of developing manufacturing methods and maintaining production lines when using biological formulations. Ultimately, for people who require new treatment methods, the program will provide the blessings of drugs at an acceptable price.