EFS function helps to gain insights into DMD research
Duchenne Muscular Dystrophy (DMD) is a progressive and fatal muscle degenerating disease caused by a dystrophin deficiency. Effective suppression of the primary pathology observed in DMD is critical for treatment. Patient-derived human induced Pluripotent Stem Cells (hiPSCs) are a promising tool for drug discovery.
Hamamatsu’s recently developed 96 well multi-Electrical Field Stimulation (EFS) function for the mCELL/FDSS system, has been used to establish an in vitro evaluation system for a DMD therapy using Patient-derived hiPSCs that recapitulate the primary pathology.
The study, conducted by researchers from Kyoto University and the Center for iPS CELL Research and Application (CiRA) has been recently published in Nature Scientific Reports, which can be viewed here.
In this study Hamamatsu’s FDSS/mCell system is effectively used to electrically stimulate and measure influx of Ca2+ into DMD myocytes in order to evaluate the early pathogenesis of these cells and thereby establish a model that helps to develop and evaluate novel drugs.
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