Researchers report encouraging preclinical results as they pursue elusive therapeutic strategies to repair scarred and poorly functioning heart tissues after cardiac injury—describing an experimental molecular treatment for heart failure. In a study in the Journal of the American College of Cardiology, researchers at the Cincinnati Children's Heart Institute inhibited a protein that helps regulate the heart's response to adrenalin...

Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice, according to research published in Cell Stem Cell. The study is believed to be the first time human colon organoids have been successfully tissue engineered in this manner, according to researchers at Cincinnati Children's Hospital Medical Center who led the project.

An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes - greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells. The scientists report online in Nature that their bioengineered human liver tissues still need additional rounds of molecular f...

Scientists report in Nature Medicine using human pluripotent stem cells to grow human intestinal tissues that have functioning nerves in a laboratory, and then using these to recreate and study a severe intestinal nerve disorder called Hirschsprung's disease. The findings describe an unprecedented approach to engineer and study tissues in the intestine - the body's largest immune organ, its food processor and main interface with th...

As cases of ADHD continue to rise among U.S. children, pediatricians at busy community practices are getting a much-needed assist from a web-based technology to improve the quality of ADHD care and patient outcomes. According to a multi-institutional study published online in Pediatrics, a web-based software program is helping reduce ADHD behavioural symptoms in children receiving care at community paediatric practices by coordinating care a...